yes there is. There's a whole topic in here somewhere on RMXP and Vista.
It would be in this thread, entitled "The problem with Vista. Check here before posting."
http://rmrk.net/index.php/topic,14361.0.htmlIn short, I had to set XP compatibility, make the exe run as administrator, and save all projects in somewhere other than c:\program files (where I installed the game itself). I never had any issues - Vista Home Basic.
If that doesn't work, I'm sure there'll be something in that thread that will help you out.