Create 2 event pages, have them both have the same NPC graphic you want them to use.
On the first page, put the 'Give Item' event, and maybe some text showing that the guy gave the item to you. At the end of this all, put the event 'Control Self Switch' and set it so Self Switch 'A' is put into the on position.
On the second page, in the conditions, put Self Switch A on (since this is the second page, it will have priority over the first page, and the first page will not be displayed again). As well, put something like the NPC getting angry for you asking for more. I tested it, and it should work.
Note: You could also use a switch or a variable, but by using a Self Switch, you prevent the off chance that somehow you'll use up all your switches and variables.