The Plague by Albert Camus. It's a novel about an outbreak of plague in a fictional Algerian city, and chronicles the life, death, and, maybe most importantly, outlook of its inhabitants, but in a really absorbing and emotional way. It is the only book to which I've ever shed a tear. It's also my favorite book, for what it's worth.
Ubik by Philip K. Dick. Sci-fi novel about a team of superhuman anti-anti-industrial espionage agents trapped in a decaying world. Philip K. Dick wrote superb sci-fi, so if you're into it definitely read his other books. I'd highly recommend The Man in the High Castle as well, but it's alternate history.
Do you like autobiographies and non-fiction?