I've been reading around on the Bethesda forums. Apparently there's a bug in the game. I think it's a little different for each person, but half the of the reports are of the game freezing just after taking the G.O.A.T. My situation is when I take a straight route from Big Town to the Police Station for whatever side quest to rescue people. I freeze every time at the top of some hill, I think I discovered it once. I think it was some sort of outdoor cinema? I don't remember, only saw it once... I just decided to not do that quest and stay away from anywhere Northwest in the game. So now I'm waiting for a patch. There was a patch already released for the PC first, then PS3 like a week ago, and then of course they leave the Xbox 360 for last.