(editing...i messed this up while writing)
Make all of your monsters have a control switch after being defeated.
Ex:
Do that for every enemy.
Now for the door. First, the message. Make a text under "Insert" and type in whatever you want your character to say, such as "To open the door, I have to kill all of the monsters first." Now click on "New Event Page" at the top and click on "2". Change the graphic in "2" as an open door (or no door at all, whatever the case might be to make it look better.) Click on Insert under the textbox (the white box) and click on "Conditional Branch". Then "Control Switches...". ONLY change the tab "Single" under "Switch". Change it to whichever event was used for your enemy (Enemy1, for ex.)For every monster there is, add a control switch after that.
Ex:
Hope this helps.
If you need any explaining, just ask.