well, DrbigT, I gotta say, there is a lot of stuff I don't like about your design choices...
You seem to have a mixture of basic sprites (modern day set), sketches (a common, acceptable choice) and here's where you lose me, the image you used for the background about 4 minutes into the last video which just doesn't come close to meshing with either making the whole experience pretty jarring.
It's actually the same problem I saw in your first video with Greed's writing, there are these orbs (which, looking back I can tell are eyeballs) and bits of flesh, I assume, falling down, but for the life of me, they are too blurry to determine what they are, they're right in your face and they're just ugly. Not in a way that makes them scary, they're just... ugly. It's the kinda thing that it seems like you have great ideas of what you want, but no one with enough graphics know-how to get you started.
It seems like, however, if you were to replace some of that kinda stuff with sprites, you would have a much nicer looking image... Something that didn't seem so... pasted together.